Paper Title: Human Immunodeficiency and Hepatitis B virus coinfection in a referral hospital, Southern Nigeria
Authors: Oboro I.L, Igbigbi E.E, Okpara C.
BACKGROUND: Liver-related disease is the leading cause of non-HIV-related mortality among HIV persons with access to antiretroviral drugs. Persons with HIV and HBV coinfection are at increased risk of serious, life-threatening complications. Coinfection rates reflect the impact of prevention/control activities geared towards these infections. The aim of this study was to determine the prevalence of HIV and HBV coinfection in the University of Port Harcourt Teaching Hospital and the age and sex distribution of co-infected individuals. METHODS: A desk review of laboratory records from July 2015 to June 2016. Serologic Test results for HIV and Hepatitis B surface antigen (HBsAg), age and sex distribution were extracted and the proportion of coinfected individuals noted. Descriptive and inferential statistics were employed using independent t test, Chi square and Fishers exact tests as appropriate. Alpha level was set at 0.05. RESULTS: Among the 752 persons positive for HIV 1/2, fourteen were also positive for Hepatitis B surface antigen, giving a HIV/ HBV coinfection rate of 1.9%. Of these, seven (2.4%) of males and seven (1.6%) of females were co-infected. Mean age of subjects was 33.0 ± 12.4years. No statistically significant difference between the HIV mono-infected and HIV/HBV coinfected groups by age and sex was observed. CONCLUSION: The prevalence of Hepatitis B/ HIV coinfection in Port Harcourt has reduced. This implies positive impact of prevention/control measures directed at these and other blood-borne pathogens. It is thus recommended that these strategies be strengthened with particular emphasis to males living with HIV.